GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BRCA | cis | rs738722 | 1 | rs1033667 | chr22:29130300 | LOC284900 | chr22:28315364-28404267:+ | 0.13 | 3.4 | 0.000697 | Esophageal cancer and gastric cancer |
| BRCA | cis | rs7515577 | 1 | rs1034219 | chr1:93022678 | EVI5 | chr1:92974255-93257961:- | -0.18 | -4.94 | 9.0E-7 | Cholesterol, total |
| BRCA | cis | rs13016963 | 1 | rs1035142 | chr2:202153078 | ALS2CR12 | chr2:202153148-202222101:- | -0.28 | -7.4 | 2.73E-13 | Melanoma;Esophageal squamous cell carcinoma |
| BRCA | cis | rs1061377 | 1 | rs1036036 | chr4:39112724 | KLHL5 | chr4:39046659-39123828:+ | -0.15 | -4.72 | 2.65E-6 | Uric acid levels |
| BRCA | cis | rs1061377 | 1 | rs1036037 | chr4:39112892 | KLHL5 | chr4:39046659-39123828:+ | -0.16 | -4.99 | 7.04E-7 | Uric acid levels |
| BRCA | cis | rs1061377 | 1 | rs1036038 | chr4:39113003 | KLHL5 | chr4:39046659-39123828:+ | -0.16 | -4.91 | 1.06E-6 | Uric acid levels |
| BRCA | cis | rs9914544 | 1 | rs1037036 | chr17:18764077 | FAM18B | chr17:18684582-18710026:+ | -0.17 | -4.66 | 3.62E-6 | Educational attainment (years of education) |
| BRCA | cis | rs9914544 | 1 | rs1037036 | chr17:18764077 | LOC220594 | chr17:18414577-18445234:- | -0.17 | -4.02 | 6.23E-5 | Educational attainment (years of education) |
| BRCA | cis | rs1039302 | 1 | rs1039302 | chr12:121236258 | SPPL3 | chr12:121201036-121342151:- | 0.18 | 4.07 | 4.95E-5 | Quantitative traits |
| BRCA | cis | rs2036402 | 1 | rs1039438 | chr5:156476770 | TIMD4 | chr5:156346293-156390266:- | -0.13 | -3.45 | 0.000587 | Hypertriglyceridemia |
| BRCA | cis | rs2243480 | 1 | rs1039664 | chr7:65449716 | CCT6P1 | chr7:65216092-65228661:+ | 0.33 | 7.19 | 1.21E-12 | Diabetic kidney disease |
| BRCA | cis | rs2243480 | 1 | rs1039664 | chr7:65449716 | LOC493754 | chr7:65993446-66057363:- | 0.2 | 3.49 | 0.000504 | Diabetic kidney disease |
| BRCA | cis | rs2243480 | 1 | rs1039664 | chr7:65449716 | ZNF117 | chr7:64434830-64467121:- | -0.26 | -4.73 | 2.55E-6 | Diabetic kidney disease |
| BRCA | cis | rs8170 | 1 | rs10402468 | chr19:17384003 | ANKLE1 | chr19:17392454-17398454:+ | 0.21 | 5.85 | 6.44E-9 | Breast cancer (estrogen-receptor negative);Breast Cancer in BRCA1 mutation carriers;Epithelial ovarian cancer;Ovarian cancer;Breast cancer |
| BRCA | cis | rs8170 | 1 | rs10402468 | chr19:17384003 | ANO8 | chr19:17434032-17445638:- | 0.15 | 3.68 | 0.000242 | Breast cancer (estrogen-receptor negative);Breast Cancer in BRCA1 mutation carriers;Epithelial ovarian cancer;Ovarian cancer;Breast cancer |